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Research associate Larisa Tratnjek, PhD

+386 1 543 76866

E-mail: larisa.tratnjek@mf.uni-lj.si

Research interests

As a research associate at the Institute of Cell Biology, Faculty of Medicine at the University of Ljubljana, my research focuses on the development and characterization of various in vitro cell models and their applicability for drug efficacy and safety testing in collaboration with pharmaceutical companies. These models include an esophageal cancer model, human nasal epithelium, and mononuclear phagocyte system. Additionally, I conduct research into the differentiation and endocytic trafficking of urothelial cells, the molecular and ultrastructural changes in preterm premature rupture of fetal membranes, and the anticancer potential of retinoids for bladder cancer treatment. My expertise is expansive, incorporating a variety of molecular approaches and microscopy techniques. During my PhD and postdoctoral research, I have explored cellular and molecular changes in animal models of neurodegenerative diseases such as Alzheimer’s and Parkinson’s disease. My passion for science is undeniable and I look forward to further advance my research.

Methodological expertise

Light microscopy (bright-filed, phase-contrast, fluorescence and confocal microscopy), electron microscopy (transmission and scanning electron microscopy), sample preparation for light and electron microscopy (ultrathin sectioning), immunolabelling, immunoelectron microscopy, freeze-fracturing, establishment and characterization of in vitro models, drug efficacy and safety testing in vitro (such as nasal drug formulations testing in in vitro human nasal epithelium by ciliary beat frequency analysis), transepithelial resistance and permeability analysis, methods for studying endocytosis, in situ hybridization, western blot, nanoparticle generation.

Bibliography

Click for full bibliography:

COBISS

Pubmed

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